Synthesis and Anticancer Activity of Some 2-[3/4-(2-Substituted Phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one Derivatives

Gündoğdu-Karaburun N., Karaburun A. Ç., Demirayak Ş., Kayağil İ., Yurttaş L.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.11, sa.5, ss.578-585, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.2174/1570180811666140403001212
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.578-585
  • Anahtar Kelimeler: 2,3-Dihydro-1H-inden-1-one, Aurone analogue, Anticancer activity, TOPOISOMERASE-I INHIBITORS, AURONE, FLAVONOIDS, CHROMONE, AGENTS, SCREEN, CELLS
  • Anadolu Üniversitesi Adresli: Evet

Özet

The synthesis of 2-[3/ 4-(2-substituted phenyl-2-oxoethoxy) benzylidene]-6-substituted-2,3-dihydro-1H-inden-1one derivatives and the investigation of their anticancer activity were studied. 2-(3- or 4-Hydroxybenzylidene)-6substituted- 2,3-dihydro-1H-inden-1-ones were reacted with suitable 2-bromoacetophenones to give 2-[3/ 4-(2-substituted phenyl-2-oxoethoxy) benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives. The structure elucidation of the synthesised compounds was performed by IR, 1H-NMR, mass spectroscopic data and elemental analyses. The anticancer screening was carried out in National Cancer Institute (NCI), USA. Notable activity was obtained for some compounds.