Synthesis and Anticancer Activity of Some 2-[3/4-(2-Substituted Phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one Derivatives


Gündoğdu-Karaburun N., Karaburun A. Ç., Demirayak Ş., Kayağil İ., Yurttaş L.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.11, no.5, pp.578-585, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.2174/1570180811666140403001212
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.578-585
  • Keywords: 2,3-Dihydro-1H-inden-1-one, Aurone analogue, Anticancer activity, TOPOISOMERASE-I INHIBITORS, AURONE, FLAVONOIDS, CHROMONE, AGENTS, SCREEN, CELLS
  • Anadolu University Affiliated: Yes

Abstract

The synthesis of 2-[3/ 4-(2-substituted phenyl-2-oxoethoxy) benzylidene]-6-substituted-2,3-dihydro-1H-inden-1one derivatives and the investigation of their anticancer activity were studied. 2-(3- or 4-Hydroxybenzylidene)-6substituted- 2,3-dihydro-1H-inden-1-ones were reacted with suitable 2-bromoacetophenones to give 2-[3/ 4-(2-substituted phenyl-2-oxoethoxy) benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives. The structure elucidation of the synthesised compounds was performed by IR, 1H-NMR, mass spectroscopic data and elemental analyses. The anticancer screening was carried out in National Cancer Institute (NCI), USA. Notable activity was obtained for some compounds.