Studies on hydrazone derivatives as antifungal agents
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.23, no.4, pp.470-475, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 23 Issue: 4
- Publication Date: 2008
- Doi Number: 10.1080/14756360701709094
- Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.470-475
- Keywords: thiazolylhydrazone, antifungal activity, Candida spp., ANTIMICROBIAL ACTIVITY, CANDIDA-ALBICANS, ANTIBACTERIAL, INHIBITORS, DESIGN
- Anadolu University Affiliated: Yes
Abstract
The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (1a-e) and N-(1-phenylbutylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (2a-e) derivatives were synthesised and evaluated for antifungal activity. Their antifungal activities against standard and clinical strands of Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, Candida zeylanoides, and Candida parapsilosis were investigated. A significant level of activity was observed.