Valnoctamide: The effect on relieving of neuropathic pain and possible mechanisms


Samur D. N., ARSLAN R., AYDIN Ş., BEKTAŞ TÜRKMEN N.

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.827, ss.208-214, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 827
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.ejphar.2018.03.006
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.208-214
  • Anahtar Kelimeler: Valnoctamide, Neuropathic pain, Chronic constriction injury, RAT MODEL, THERMAL HYPERALGESIA, DESCENDING CONTROL, SEROTONIN, ALLODYNIA, RECEPTOR, INJURY, OPIOIDS, DRUGS
  • Anadolu Üniversitesi Adresli: Evet

Özet

The purpose of this study is to assess the possible anti-allodynic and antihyperalgesic effect of valnoctamide, an amide derivative of valproic acid, at the doses of 40, 70 and 100 mg/kg (i.p.) in neuropathic pain model induced by chronic constriction injury in rats, by using dynamic plantar test and plantar test (Hargreaves method), and to evaluate that the possible role of certain serotonin, noradrenergic, opioid and GABAergic receptors by pretreatment with 1 mg/kg (i.p.) ketanserin, yohimbine, naloxone and 0.5 mg/kg (i.p.) bicuculline, respectively. 70 and 100 mg/kg valnoctamide significantly increased the mechanical and thermal thresholds decreasing with the development of neuropathy and demonstrated anti-allodynic and antihyperalgesic activity. Limited contribution of serotonin 5-HT2A/2C receptors and alpha 2-adrenoceptors, and significant contribution of GABA(A) and opioid receptors to the anti-allodynic activity have been identified whereas remarkable contribution of opioid receptors and significant contribution of serotonin 5-HT2A/2C receptors, alpha 2-adrenoceptors, GABA(A) receptors to the antihyperalgesic activity have been identified. Based upon these findings and considering that valnoctamide has safer side-effect profile, it is possible to say that valnoctamide is a potential agent that might be used alone or in combination with the other effective therapies in the alleviating of neuropathic pain.