Evaluation of Effects of Quercetin (3, 3 ', 4 ', 5, 7-pentohidroxyflavon) on Apoptosis and Telomerase Enzyme Activity in MCF-7 and NIH-3T3 Cell Lines Compared with Tamoxifen

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AK A., Basaran A., DİKMEN M., TURGUT COŞAN D., DEĞİRMENCİ İ., Gunes H. V.

BALKAN MEDICAL JOURNAL, vol.28, no.3, pp.293-299, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.5174/tutfd.2010.03372.3
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.293-299
  • Keywords: MCF-7, NIH-3T3, quercetin, tamoxifen, telomerase activity, apoptosis, BREAST-CANCER CELLS, ESTROGEN-RECEPTOR, GROWTH-INHIBITION, DOWN-REGULATION, SUPPRESSION, EXPRESSION, INDUCTION, SURVIVIN, DEATH, HEPG2
  • Anadolu University Affiliated: Yes

Abstract

Objective: Quercetin has been shown to inhibit the proliferation of cancer cells. Tamoxifen is used for breast cancer. In this study, we have aimed to investigate the effects of quercetin and tamoxifen on telomerase enzyme activity and apoptosis in two cell lines.