Evaluation of Effects of Quercetin (3, 3 ', 4 ', 5, 7-pentohidroxyflavon) on Apoptosis and Telomerase Enzyme Activity in MCF-7 and NIH-3T3 Cell Lines Compared with Tamoxifen

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AK A., Basaran A., DİKMEN M., TURGUT COŞAN D., DEĞİRMENCİ İ., Gunes H. V.

BALKAN MEDICAL JOURNAL, cilt.28, sa.3, ss.293-299, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5174/tutfd.2010.03372.3
  • Dergi Adı: BALKAN MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.293-299
  • Anahtar Kelimeler: MCF-7, NIH-3T3, quercetin, tamoxifen, telomerase activity, apoptosis, BREAST-CANCER CELLS, ESTROGEN-RECEPTOR, GROWTH-INHIBITION, DOWN-REGULATION, SUPPRESSION, EXPRESSION, INDUCTION, SURVIVIN, DEATH, HEPG2
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objective: Quercetin has been shown to inhibit the proliferation of cancer cells. Tamoxifen is used for breast cancer. In this study, we have aimed to investigate the effects of quercetin and tamoxifen on telomerase enzyme activity and apoptosis in two cell lines.