A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity

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SEVER B., ALTINTOP M. D., Demir Y., TÜRKEŞ C., Ozbas K., AKALIN ÇİFTÇİ G., ...Daha Fazla

OPEN CHEMISTRY, cilt.19, sa.1, ss.347-357, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1515/chem-2021-0032
  • Dergi Adı: OPEN CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.347-357
  • Anahtar Kelimeler: aldose reductase, thiazolidinedione, cytotoxicity, molecular docking, IN-SILICO, CARBONIC-ANHYDRASE, DERIVATIVES, VITRO, ACETYLCHOLINESTERASE, COMPLICATIONS, INSIGHTS, TARGETS, DESIGN
  • Anadolu Üniversitesi Adresli: Evet

Özet

In an effort to identify potent aldose reductase (AR) inhibitors, 5-(arylidene)thiazolidine-2,4-diones (1-8), which were prepared by the solvent-free reaction of 2,4-thiazolidinedione with aromatic aldehydes in the presence of urea, were examined for their in vitro AR inhibitory activities and cytotoxicity. 5-(2-Hydroxy-3-methylbenzylidene)thiazolidine-2,4-dione (3) was the most potent AR inhibitor in this series, exerting uncompetitive inhibition with a K-i value of 0.445 +/- 0.013 mu M. The IC50 value of compound 3 for L929 mouse fibroblast cells was determined as 8.9 +/- 0.66 mu M, pointing out its safety as an AR inhibitor. Molecular docking studies suggested that compound 3 exhibited good affinity to the binding site of AR (PDB ID: 4JIR). Based upon in silico absorption, distribution, metabolism, and excretion data, the compound is predicted to have favorable pharmacokinetic features. Taking into account the in silico and in vitro data, compound 3 stands out as a potential orally bioavailable AR inhibitor for the management of diabetic complications as well as nondiabetic diseases.