Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits

Oezkay U. D., CAN Ö. D., ÖZKAY Y., ÖZTÜRK Y.

PHARMACOLOGICAL REPORTS, vol.64, no.4, pp.834-847, 2012 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1016/s1734-1140(12)70878-2
  • Journal Name: PHARMACOLOGICAL REPORTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.834-847
  • Keywords: Alzheimer's disease, streptozotocin, donepezil, acetylcholinesterase, elevated plus maze test, Morris water maze test, active avoidance test, benzothiazole/piperazine, POTENTIAL ANTIDEMENTIA DRUG, GAMMA-SECRETASE INHIBITORS, N-ARYLSULFONYL PIPERIDINES, ALZHEIMERS-DISEASE, ACETYLCHOLINESTERASE INHIBITOR, INDUCED NEUROTOXICITY, HIPPOCAMPAL SLICES, MEMORY IMPAIRMENT, FRONTAL-CORTEX, RATS
  • Anadolu University Affiliated: Yes

Abstract

Background: In this study, benzothiazolc-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's disease, with the aim of obtaining new and potent anti-Alzheimer agents.