Copy For Citation
Oezkay U. D., CAN Ö. D., ÖZKAY Y., ÖZTÜRK Y.
PHARMACOLOGICAL REPORTS, vol.64, no.4, pp.834-847, 2012 (SCI-Expanded)
-
Publication Type:
Article / Article
-
Volume:
64
Issue:
4
-
Publication Date:
2012
-
Doi Number:
10.1016/s1734-1140(12)70878-2
-
Journal Name:
PHARMACOLOGICAL REPORTS
-
Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
-
Page Numbers:
pp.834-847
-
Keywords:
Alzheimer's disease, streptozotocin, donepezil, acetylcholinesterase, elevated plus maze test, Morris water maze test, active avoidance test, benzothiazole/piperazine, POTENTIAL ANTIDEMENTIA DRUG, GAMMA-SECRETASE INHIBITORS, N-ARYLSULFONYL PIPERIDINES, ALZHEIMERS-DISEASE, ACETYLCHOLINESTERASE INHIBITOR, INDUCED NEUROTOXICITY, HIPPOCAMPAL SLICES, MEMORY IMPAIRMENT, FRONTAL-CORTEX, RATS
-
Anadolu University Affiliated:
Yes
Abstract
Background: In this study, benzothiazolc-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's disease, with the aim of obtaining new and potent anti-Alzheimer agents.