Activated N-ras oncogene inhibits the expression of PDGF-beta receptor in myoblast cells

Zeytinoglu H., Griffiths S., Gibson I.

EXPERIMENTAL ONCOLOGY, vol.24, no.2, pp.116-119, 2002 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 2002
  • Journal Name: EXPERIMENTAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.116-119
  • Keywords: N-ras, MyoD1, platelet-derived growth factor type-beta receptor, myoblast, GROWTH-FACTOR, INSULIN-RECEPTOR, MESSENGER-RNA, DIFFERENTIATION, FIBROBLASTS, PROTEIN, PHOSPHATASE, SUPPRESSION, REDUCTION, P21(RAS)
  • Anadolu University Affiliated: No

Abstract

By RT-PCR technique mRNA levels of platelet-derived growth factor type-beta receptor (PDGF-beta-R) and MyoD1 in a myoblast cell line carrying human N-ras oncogene have been investigated. After dexamethasone treatment an activation of N-ras and inhibition of the PDGF-beta-R and MyoD1 genes transcription was observed. Those results suggested that cells transformed with the N-ras oncogene fail to respond to PDGF-BB due to the absence of PDGF-beta-R mRNA.