Activated N-ras oncogene inhibits the expression of PDGF-beta receptor in myoblast cells
EXPERIMENTAL ONCOLOGY, cilt.24, sa.2, ss.116-119, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 2
- Basım Tarihi: 2002
- Dergi Adı: EXPERIMENTAL ONCOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.116-119
- Anahtar Kelimeler: N-ras, MyoD1, platelet-derived growth factor type-beta receptor, myoblast, GROWTH-FACTOR, INSULIN-RECEPTOR, MESSENGER-RNA, DIFFERENTIATION, FIBROBLASTS, PROTEIN, PHOSPHATASE, SUPPRESSION, REDUCTION, P21(RAS)
- Anadolu Üniversitesi Adresli: Hayır
Özet
By RT-PCR technique mRNA levels of platelet-derived growth factor type-beta receptor (PDGF-beta-R) and MyoD1 in a myoblast cell line carrying human N-ras oncogene have been investigated. After dexamethasone treatment an activation of N-ras and inhibition of the PDGF-beta-R and MyoD1 genes transcription was observed. Those results suggested that cells transformed with the N-ras oncogene fail to respond to PDGF-BB due to the absence of PDGF-beta-R mRNA.