Copy For Citation
Zeytinoglu H., Griffiths S., Gibson I.
EXPERIMENTAL ONCOLOGY, vol.24, no.2, pp.116-119, 2002 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
24
Issue:
2
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Publication Date:
2002
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Journal Name:
EXPERIMENTAL ONCOLOGY
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.116-119
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Keywords:
N-ras, MyoD1, platelet-derived growth factor type-beta receptor, myoblast, GROWTH-FACTOR, INSULIN-RECEPTOR, MESSENGER-RNA, DIFFERENTIATION, FIBROBLASTS, PROTEIN, PHOSPHATASE, SUPPRESSION, REDUCTION, P21(RAS)
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Anadolu University Affiliated:
No
Abstract
By RT-PCR technique mRNA levels of platelet-derived growth factor type-beta receptor (PDGF-beta-R) and MyoD1 in a myoblast cell line carrying human N-ras oncogene have been investigated. After dexamethasone treatment an activation of N-ras and inhibition of the PDGF-beta-R and MyoD1 genes transcription was observed. Those results suggested that cells transformed with the N-ras oncogene fail to respond to PDGF-BB due to the absence of PDGF-beta-R mRNA.