Enhancement in dissolution pattern of piribedil by molecular encapsulation with beta-cyclodextrin

Demirel M., Buyukkoroglu G., Kalava B., Yazan Y.

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, cilt.28, sa.2, ss.83-88, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1358/mf.2006.28.2.977838
  • Dergi Adı: METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.83-88
  • Anahtar Kelimeler: beta-cyclodextrin, molecular encapsulation, piribedil, WATER-SOLUBLE POLYMERS, INCLUSION COMPLEXES, PHYSICOCHEMICAL PROPERTIES, SOLID-STATE, DRUG, VINPOCETINE, SOLUBILITY, BEHAVIOR, ACID
  • Anadolu Üniversitesi Adresli: Hayır

Özet

The aim of this was to improve the dissolution behavior of piribedil by molecular encapsulation with beta-cyclodextrin (beta-CD). Toward this aim, physical mixing, co-grinding, and spray-drying methods were used to prepare solid binary sytems. Differential scanning calorimetry, X-ray diffractomertry, and particle size analysis were used to characterize the binary systems obtained. Complexes of piribedil and beta-CD could be prepared using the spray-drying method. Dissolution of piribedil was improved to a great extent by the complex prepared. (c) 2006 Prous Science. All rights reserved.