Enhancement in dissolution pattern of piribedil by molecular encapsulation with β-cyclodextrin

Demirel M., Buyukkoroglu G., Kalava B., Yazan Y.

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, no.2, pp.83-88, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2006
  • Doi Number: 10.1358/mf.2006.28.2.977838
  • Journal Name: METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.83-88
  • Keywords: beta-cyclodextrin, molecular encapsulation, piribedil, WATER-SOLUBLE POLYMERS, INCLUSION COMPLEXES, PHYSICOCHEMICAL PROPERTIES, SOLID-STATE, DRUG, VINPOCETINE, SOLUBILITY, BEHAVIOR, ACID
  • Anadolu University Affiliated: Yes

Abstract

The aim of this was to improve the dissolution behavior of piribedil by molecular encapsulation with beta-cyclodextrin (beta-CD). Toward this aim, physical mixing, co-grinding, and spray-drying methods were used to prepare solid binary sytems. Differential scanning calorimetry, X-ray diffractomertry, and particle size analysis were used to characterize the binary systems obtained. Complexes of piribedil and beta-CD could be prepared using the spray-drying method. Dissolution of piribedil was improved to a great extent by the complex prepared. (c) 2006 Prous Science. All rights reserved.