Preparation of prolonged release clarithromycin microparticles for oral use and their in vitro evaluation

Genc L., Demirel M., Yazan Y.

ARCHIVES OF PHARMACAL RESEARCH, cilt.29, sa.10, ss.921-927, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 10
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/bf02973915
  • Dergi Adı: ARCHIVES OF PHARMACAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.921-927
  • Anahtar Kelimeler: prolonged release, microparticle, clarithromycin, Eudragit RL 100 and RS 100, spray-drying, casting-drying, PERFORMANCE LIQUID-CHROMATOGRAPHY, PHYSICOCHEMICAL PROPERTIES, ELECTROCHEMICAL DETECTION, FORMULATION, INFECTION, PHARMACOKINETICS, MICROSPHERES, ERYTHROMYCIN, DISSOLUTION, STABILITY
  • Anadolu Üniversitesi Adresli: Evet

Özet

Prolonged release microparticles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, particle size distribution, X-ray diffraction, thermal behavior, active agent content and in vitro dissolution from the microparticles were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. All the formulations obtained showed prolonged release when compared to pure clarithromycin. Microparticles prepared by spray-drying method had a slower release compared to those of casting-drying method. Spray-drying method seems to be a more suitable method to prepare microparticles for prolongation in release.