Both recovery and effective removing of radioactive thallium and iodine are important subject to protect human health and the environment. In this study, we have studied synergistic and cost-effective cryogel based sorbents by combining the high selectivity adsorption ability of MIP and the high porosity of cryogels. For thallium-imprinted cryogel; N-methacryloyl-(l)-cysteine (MAC) has synthesized, MAC has complexed with thallium ion and polymer cryogel has been prepared. For iodine-imprinted cryogel; MAC-thallium has complexed with iodine; and polymer cryogel has been prepared. Then, the adsorption, desorption, selectivity and reusability experiments have been carried out.