Effects of carvacrol on sister chromatid exchanges in human lymphocyte cultures
15th Annual Meeting of the Japanese-Association-for-Animal-Cell-Technology, Fuchu, Japonya, 11 - 15 Kasım 2002, ss.471-474, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Doi Numarası: 10.1023/b:cyto.0000039896.26707.40
- Basıldığı Şehir: Fuchu
- Basıldığı Ülke: Japonya
- Sayfa Sayıları: ss.471-474
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Anadolu Üniversitesi Adresli: Hayır
Özet
Carvacrol is a predominant aromatic compound in oil of oregano. It has naturally remarkable antibacterial, antiviral, antifungal and antiparasital effects. In this study, genotoxic and antigenotoxic activities of carvacrol were investigated by the in vitro sister chromatid exchange (SCE) assay on human peripheral blood lymphocytes. Inhibitory effect of carvacrol was tested in the presence of mitomycin C (MMC) in the same assay. According to data, all doses of carvacrol did not increase the formation of SCE, whereas it inhibited the rate of SCE induced by MMC. In conclusion, carvacrol exhibited a significant antigenotoxic activity in mammalian cells, indicating its potential for use as an antigenotoxic agent.