Effects of carvacrol on sister chromatid exchanges in human lymphocyte cultures

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Ipek E., Tuylu B., Zeytinoglu H.

15th Annual Meeting of the Japanese-Association-for-Animal-Cell-Technology, Fuchu, Japan, 11 - 15 November 2002, pp.471-474 identifier identifier

  • Publication Type: Conference Paper / Full Text
  • Doi Number: 10.1023/b:cyto.0000039896.26707.40
  • City: Fuchu
  • Country: Japan
  • Page Numbers: pp.471-474
  • Anadolu University Affiliated: No


Carvacrol is a predominant aromatic compound in oil of oregano. It has naturally remarkable antibacterial, antiviral, antifungal and antiparasital effects. In this study, genotoxic and antigenotoxic activities of carvacrol were investigated by the in vitro sister chromatid exchange (SCE) assay on human peripheral blood lymphocytes. Inhibitory effect of carvacrol was tested in the presence of mitomycin C (MMC) in the same assay. According to data, all doses of carvacrol did not increase the formation of SCE, whereas it inhibited the rate of SCE induced by MMC. In conclusion, carvacrol exhibited a significant antigenotoxic activity in mammalian cells, indicating its potential for use as an antigenotoxic agent.