Preparation of some pyrazoline derivatives and evaluation of their antifungal activities
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.25, no.4, pp.565-571, 2010 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 25 Issue: 4
- Publication Date: 2010
- Doi Number: 10.3109/14756360903373368
- Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.565-571
- Keywords: Pyrazoline, antifungal activity, Candida spp., ANTIMICROBIAL ACTIVITIES, THIABENDAZOLE, ANTIBACTERIAL
- Anadolu University Affiliated: Yes
Abstract
The synthesis of a new series of 1-[( benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-( chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, and FAB(+)-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed.