Convenient synthesis of C-terminal di- and tri-peptide amides from N-protected dipeptidoylbenzotriazoles

ÇELİK İ., Abdel-Fattah A. A. A.

TETRAHEDRON, vol.65, no.25, pp.4923-4929, 2009 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 65 Issue: 25
  • Publication Date: 2009
  • Doi Number: 10.1016/j.tet.2009.02.070
  • Journal Name: TETRAHEDRON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.4923-4929
  • Anadolu University Affiliated: Yes

Abstract

N-Protected dipeptidoylbeiizotriazoles react with aqueous ammonia to give dipeptide primary amides (77-98%) and with N-unprotected alpha-amino amides to afford tripeptide primary amides (82-86%). (C) 2009 Published by Elsevier Ltd.