Synthesis and Antimicrobial Activity of some Amide Derivatives Bearing Thiazole, Benzhydryl and Piperidine Moieties

ÖZDEMİR A.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.10, sa.1, ss.44-48, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.2174/157018013804142410
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.44-48
  • Anahtar Kelimeler: Amide, Thiazole, Benzhydryl, Piperidine, Antimicrobial activity
  • Anadolu Üniversitesi Adresli: Evet

Özet

In the present study, N-(benzhydryl/thiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives were obtained by the reaction of 2-chloro-N-(benzhydryl/thiazole-2-yl)acetamides with piperidine derivatives. The chemical structures of the compounds were elucidated by IR, H-1-NMR, and mass spectral data and elemental analyses. These compounds were investigated for their antimicrobial effects. The microbiological results revealed that the compounds were more effective against C. albicans (ATCC-22019) than bacteria. Among all compounds (1-9), compound 3 bearing benzhydryl and 4-methylpiperidin-1-yl moieties was found to be the most effective compound against C. albicans. Compound 3 exhibited antibacterial activity against P. aeruginosa with a MIC value of 62.5 mu g/mL, whereas streptomycin showed antibacterial activity against P. aeruginosa with a MIC value of 125 mu g/mL. Furthermore, compound 3 exhibited the same level of antibacterial activity against S. aureus when compared with streptomycin. Other derivatives did not show significant activity against the tested bacteria.