Synthesis and Evaluation of Tetrazole-Based Hydrazone Derivatives Bearing a Pyridine Moiety as Antimicrobial Agents

ÖZDEMİR A., ALTINTOP M. D., SEVER B., CANTÜRK Z., KAPLANCIKLI Z. A.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.12, sa.8, ss.687-693, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1570180812666150309235217
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.687-693
  • Anahtar Kelimeler: Antimicrobial activity, cytotoxicity, hydrazone, pyridine, tetrazole, BIOLOGICAL EVALUATION, ANTIFUNGAL, PROLIFERATION, ASSOCIATION, RESISTANCE
  • Anadolu Üniversitesi Adresli: Evet

Özet

2-[(1-Methyl/Phenyl-1H-tetrazol-5-yl)thio]-N'-[(aryl) methylidene/ethylidene] acetohydrazides were synthesized and investigated in vitro against pathogenic bacteria and Candida species for their antimicrobial activity using CLSI broth microdilution method. MTT assay was also carried out to evaluate their cytotoxic effects on NIH/3T3 mouse embryonic fibroblast cell lines. 2-((1-Phenyl-1H-tetrazol-5-yl)thio)-N'-(1-(pyridin-3-yl)ethylidene) acetohydrazide can be considered as the most promising antibacterial agent against Enterococcus faecalis (ATCC 29212) with a MIC value of 100 mu g/mL when compared with chloramphenicol (MIC = 200 mu g/mL) and low toxicity against NIH/3T3 cells (IC50>500 mu g/mL).