Synthesis and Evaluation of Tetrazole-Based Hydrazone Derivatives Bearing a Pyridine Moiety as Antimicrobial Agents

ÖZDEMİR A., ALTINTOP M. D., SEVER B., CANTÜRK Z., KAPLANCIKLI Z. A.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.12, no.8, pp.687-693, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.2174/1570180812666150309235217
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.687-693
  • Keywords: Antimicrobial activity, cytotoxicity, hydrazone, pyridine, tetrazole, BIOLOGICAL EVALUATION, ANTIFUNGAL, PROLIFERATION, ASSOCIATION, RESISTANCE
  • Anadolu University Affiliated: Yes

Abstract

2-[(1-Methyl/Phenyl-1H-tetrazol-5-yl)thio]-N'-[(aryl) methylidene/ethylidene] acetohydrazides were synthesized and investigated in vitro against pathogenic bacteria and Candida species for their antimicrobial activity using CLSI broth microdilution method. MTT assay was also carried out to evaluate their cytotoxic effects on NIH/3T3 mouse embryonic fibroblast cell lines. 2-((1-Phenyl-1H-tetrazol-5-yl)thio)-N'-(1-(pyridin-3-yl)ethylidene) acetohydrazide can be considered as the most promising antibacterial agent against Enterococcus faecalis (ATCC 29212) with a MIC value of 100 mu g/mL when compared with chloramphenicol (MIC = 200 mu g/mL) and low toxicity against NIH/3T3 cells (IC50>500 mu g/mL).