Synthesis and antituberculosis activity of some N-pyridyl-N '-thiazolylhydrazine derivatives

Turan-Zitouni G., KAPLANCIKLI Z. A., ÖZDEMİR A.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.45, sa.5, ss.2085-2088, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.ejmech.2010.01.017
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.2085-2088
  • Anahtar Kelimeler: Antituberculosis activity, Hydrazine, Thiazole, Pyridine, Mycobacterium tuberculosis, MYCOBACTERIUM-TUBERCULOSIS, IN-VITRO, DRUG-RESISTANCE, AGENTS, MECHANISMS, VIVO
  • Anadolu Üniversitesi Adresli: Evet

Özet

In this study, new N-(1-arylethylidene)-N'-(4-arylthiazol-2-yl)hydrazine derivatives were synthesized and evaluated for their antituberculosis activity. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and Elemental Analyses. The initial screen was conducted against Mycobacterium tuberculosis H37Rv (ATCC 27294) in BACTEC 12B medium using the Microplate Alamar Blue Assay (MABA). The VERO cell cytotoxicity assay was done in parallel with the TB Dose Response assay. Viability was assessed using Promega's Cell Titer-Glo Luminescent Cell Viability Assay. Cytotoxicity was determined from the dose-response curve as the CC50 using a curve-fitting program. One of the compounds showed high activity with low toxicity. (C) 2010 Elsevier Masson SAS. All rights reserved.