LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.4, pp.414-427, 2018 (SCI-Expanded)
Article / Article
LETTERS IN DRUG DESIGN & DISCOVERY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Thiophene, 3-phenyl-2-pyrazoline, benzothiazole, acetylcholinesterase, Monoamine oxidase (MAO), MAO inhibitors, Alzheimer's disease, molecular docking, MONOAMINE-OXIDASE, BIOLOGICAL EVALUATION, COGNITIVE DYSFUNCTION, DESIGN
Anadolu University Affiliated:
Background: Alzheimer's Disease (AD) is a complicated neurodegenerative disorder with a multifaceted pathogenesis. AD, characterized by gradual memory loss, falling in language ability and other cognitive deterioration, and has been a prominent risk to ageing population. This means that there is an urgent need to find new lead compounds for controlling and fighting against (AD). In this way, a new thiophene-2-pyrazoline derivatives (A1-A5) and benzothiazole derivatives (A6-A13) have been synthesized to give beneficial compounds to controlling and battling against (AD).