EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol.7, no.3, pp.215-220, 1999 (SCI-Expanded)
The voltammetric behaviors of trazodone using a platinum electrode in stationary or rotating conditions and its determination in tablets by DP rotating electrodes are described in this study. The experiments were conducted in the supporting electrolyte consisting of 0.2 M KCl and 0.2 M acetate or phosphate buffer. No adsorption was observed at +300 mV. The factor affecting the voltammetric current was diffusional in the range of 200-2000 rpm for rotating, and 2-10 mV potential rate for stationary conditions; and the calibration dependence was linear between 1x10(-5)-5x10(-5) M trazodone solutions. The detection limit was found to be 2.5x10(-6) M (s(b)=5.03, n=5) for stationary and 1.7x10(-6) M (s(b)=2.12, n=5) for rotating electode assuming a signal to noise ratio of 3. According to the statistical evaluations, acceptable results were obtained at the 95% probability level. Therefore, the proposed method is practicable, sensitive and accurate for the analysis of trazodone preparations in quality control laboratories. (C) 1999 Elsevier Science B.V. All rights reserved.