N-(alpha-Amidoalkyl)benzotriazole-mediated synthesis of beta '-amido beta-diketones: a general synthetic protocol for N-[beta-(3,5-di and 1,3,5-trisubstituted pyrazol-4-yl)alkyl] amides
TETRAHEDRON, cilt.65, sa.1, ss.328-335, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 65 Sayı: 1
- Basım Tarihi: 2009
- Doi Numarası: 10.1016/j.tet.2008.10.047
- Dergi Adı: TETRAHEDRON
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC), Current Chemical Reactions (CCR)
- Sayfa Sayıları: ss.328-335
- Anahtar Kelimeler: Benzotriazole, N-(alpha-Amidoalkyl)benzotriazole, Pyrazole, beta '-Amido beta-diketone, VERSATILE AMIDOALKYLATION REAGENTS, ONE-POT SYNTHESIS, 1,3-DIPOLAR CYCLOADDITIONS, REGIOSELECTIVE SYNTHESIS, PYRAZOLE DERIVATIVES, CONVENIENT SYNTHESIS, DICARBONYL-COMPOUNDS, 1,3-AMINO ALCOHOLS, CARBONYL-COMPOUNDS, BENZOTRIAZOLE
- Anadolu Üniversitesi Adresli: Evet
Özet
Various beta '-amido-beta-diketones were first synthesized with N-(alpha-amidoalkyl)benzotriazole-mediated amidoalkylation of 1,3-diketones in moderate yields. These intermediates undergo rapid condensation with hydrazines to give the corresponding N-[beta-(3,5-di and 1,3,5-trisubstituted pyrazol-4-yl)alkyl]amides. (C) 2008 Elsevier Ltd. All rights reserved.