Synthesis of Some Thienyl-Triazine Derivatives and Antimicrobial Activity

Kaplancikli Z. A., Turan-Zirouni G., ÖZDEMİR A., ALTINTOP M. D., Tunali Y.

ASIAN JOURNAL OF CHEMISTRY, sa.9, ss.6701-6707, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2010
  • Dergi Adı: ASIAN JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6701-6707
  • Anahtar Kelimeler: Triazine, Thiophene, Thiocarbohydrazide, Antimicrobial activity, CONDENSED 1,2,4-TRIAZINES, HETEROCYCLES, CEPHALOSPORIN, SERIES, AGENTS, RINGS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Some 4-(1-aryl-ethylideneamino)-5-phenyl-1,4-dihydro-2H-[2,4]triazine-3-thione derivatives were synthesized and evaluated for their antimicrobial activity. The reaction of 2-acetylfuran or 2-acetyl-thiophene with thiocarbohydrazide yielded the N-(1-arylethylidene) thiocarbohydrazides which furnished the derivatives by reacting with phenacyl bromides. The chemical structures of the compounds were elucidated by IR, (1)H NMR and FAB(+)-MS spectral data and elemental analyses. Microdilution broth susceptibility assay was used for the antimicrobial activity evaluation of the compounds against the strains Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia spp., Salmonella thyphimurium, Proteus vulgaris, Listeria monocytogenes, Candida glabrata, Candida albicans; Candida tropicalis. Chloramphenicol and ketoconazole were used as control drugs. A significant level of activity was observed.