Synthesis, anticandidal activity and cytotoxicity of some tetrazole derivatives

KAPLANCIKLI Z. A., YURTTAŞ L., ÖZDEMİR A., Turan-Zitouni G., İŞCAN G., AKALIN ÇİFTÇİ G., ...More

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.29, no.1, pp.43-48, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.3109/14756366.2012.752363
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.43-48
  • Keywords: Anticandidal activity, azole, cytotoxicity, tetrazole, BIOLOGICAL EVALUATION, ANTIFUNGAL, INHIBITORS
  • Anadolu University Affiliated: Yes

Abstract

In this study, 14 different 2-[(1-methyl-1H-tetrazole-5-yl)thio]-1-(phenyl) ethanone derivatives (1-14) were synthesized. The structures of the obtained compounds were elucidated using IR, H-1-NMR, C-13-NMR and FAB(+)-MS spectral data and elemental analyses results. The compounds were screened for their anticandidal activity using the microbroth dilution method and for their cytotoxic effects using the MTT assay against NIH/3T3 cells. Some of the compounds were found to be potent anticandidal agents with weak cytotoxicities.