REVISTA DE CHIMIE, vol.57, no.12, pp.1247-1252, 2006 (SCI-Expanded)
Five 2-aryl-substituted-benzothiazoles were synthesized from o-amino-thiophenol and their structural assignments were made by H-1-NMR. Mutagenicily of derivatives was tested by Salmonella microsome assay using TA98 and TA100.2-m-tolil-benzothiazole and 2-p-tolil-benzothiazole whose phenyl rings possess methyl group showed significant mutagenic activity in T100, whereas they were cytotoxic for TA98. 2-pyridin-2-yl-benzothiazole was weakly mutagenic. Tested compounds may show different genotoxicity regarding to electronic properly of alkyl substituent which is attached to phenyl ring at the second position of benzothiazole.