Synhesis and genotoxic activities of five 2-aryl-substituted-benzothiazole derivatives

Zeytinoglu H., Meryc A., Tuylu B., Ergene E.

REVISTA DE CHIMIE, vol.57, no.12, pp.1247-1252, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 12
  • Publication Date: 2006
  • Journal Name: REVISTA DE CHIMIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1247-1252
  • Keywords: genotoxicily, Salmonella microsome test, benzothiazole, SOLVENT-FREE SYNTHESIS, ANTITUMOR BENZOTHIAZOLES, POTENT, 2-ARYLBENZOTHIAZOLES, BENZIMIDAZOLES, MUTAGENICITY, AGENTS
  • Anadolu University Affiliated: Yes

Abstract

Five 2-aryl-substituted-benzothiazoles were synthesized from o-amino-thiophenol and their structural assignments were made by H-1-NMR. Mutagenicily of derivatives was tested by Salmonella microsome assay using TA98 and TA100.2-m-tolil-benzothiazole and 2-p-tolil-benzothiazole whose phenyl rings possess methyl group showed significant mutagenic activity in T100, whereas they were cytotoxic for TA98. 2-pyridin-2-yl-benzothiazole was weakly mutagenic. Tested compounds may show different genotoxicity regarding to electronic properly of alkyl substituent which is attached to phenyl ring at the second position of benzothiazole.