Synthesis and biological screening of some novel triazole derivatives Bazı yeni triazol türevlerinin sentezi ve biyolojik aktivilerinin incelenmesi

Acar U., Abumohsen U., ÖZKAY Y., KARACA H., KAPLANCIKLI Z. A.

Turkish Journal of Pharmaceutical Sciences, cilt.12, sa.2, ss.221-230, 2015 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5505/tjps.2015.36855
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.221-230
  • Anahtar Kelimeler: Anticandidal, Anticholinesterase, Triazole
  • Anadolu Üniversitesi Adresli: Evet

Özet

© 2015, Turkish Pharmacists Association. All rights reserved.In the present study 15 novel triazole compounds were synthesized in order to investigate their anticandidal and anticholinesterase activities. Structures of the synthesized compounds were elucidated by spectral data and elemental analyses. Anticandidal activity tests were performed against four different fungal strains. Compounds 4j, 4k, and 4l displayed moderate anticandidal activity against Candida glabrata (ATCC 90030) and Candida albicans (ATCC 10231). Anticholinesterase activity of the synthesized compounds against acetylcholinesterase (AChE) was also studied. However synthesized compounds did not indicate important enzyme inhibition.