Ducrosia ismaelis Asch. essential oil: chemical composition profile and anticancer, antimicrobial and antioxidant potential assessment

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Mothana R. A., Nasr F. A., Khaled J. M., Noman O. M., Abutaha N., Al-Rehaily A., ...Daha Fazla

OPEN CHEMISTRY, cilt.18, sa.1, ss.175-184, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/chem-2020-0019
  • Dergi Adı: OPEN CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.175-184
  • Anahtar Kelimeler: Ducrosia ismaelis, essential oil, GC, GC/MS, cytotoxic, antimicrobial, antioxidant, ANETHIFOLIA DC. BOISS., ASSADII ALAVA., CYTOTOXIC ACTIVITY, KERMAN PROVINCE, PLANT, APOPTOSIS, CONSTITUENTS, LEAVES
  • Anadolu Üniversitesi Adresli: Evet

Özet

The essential oil of Ducrosia ismaelis Asch. (Apiaceae) that grows wild in Saudi Arabia was investigated utilizing gas chromatography (GC), and gas chromatography-mass spectrometry. Fifty constituents were characterized, representing 96.1% of the total oil. The D. ismaelis essential oil (DIED) was distinguished by a high composition of oxygenated monoterpenes (51.6%). Decanal (40.6%), alpha-pinene (15.1%) and dodecanal (13.7%) were the fundamental components. Additionally, DIED was evaluated for its cytotoxic, antibacterial, antifungal and antioxidant activities. DIED revealed a great cytotoxic effectiveness against the tested cancer cell lines with IC50 values between 66.2 and 137.3 mu g/mL particularly against MCF-7 cancer cells. Furthermore, the induction of apoptosis against MCF-7 cells has been asserted using staining assay (annexin VFITC and/or propidium iodide (PI) dyes) and flow cytometry technique. The DIED possessed a strong antimicrobial activity against Gram-positive bacterial and fungal strains with MIC-values between 0.07 and 0.31 mg/ml. The values of MBC or MFC were almost once higher than those of MIC's. Moreover, the beta-carotene-bleaching and DPPH free radical-scavenging tests showed that DIED had a moderate activity (68%) as an antioxidant agent in decolouring of the beta-carotene at 1.0 mg/mL and a moderate radical scavenging for DPPH (66 and 72%) at 0.50 and 1.0 mg/mL.