Design, Synthesis and Biological Evaluation of a Novel Series of Thiadiazole-Based Anticancer Agents as Potent Angiogenesis Inhibitors

Altug-Tasa B., Kaya-cavusoglu B., Koparal A. T., TURAN G., Koparal A. S., KAPLANCIKLI Z. A.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.21, no.15, pp.2041-2049, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 15
  • Publication Date: 2021
  • Doi Number: 10.2174/1871520621666201231143535
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.2041-2049
  • Keywords: Benzothiazole, thiadiazole, thiazole, anticancer activity, angiogenesis, MTT, WST-1, 1,3,4-THIADIAZOLE, DERIVATIVES, BENZOTHIAZOLES, CYTOTOXICITY, ANTIOXIDANT, CARCINOMA, MOIETY
  • Anadolu University Affiliated: Yes

Abstract

Background: Thiadiazole has attracted a great deal of interest as a versatile heterocycle for the discovery and development of potent anticancer agents. Thiadiazole derivatives exert potent antitumor activity against a variety of human cancer cell lines through various mechanisms.