Design, Synthesis and Biological Evaluation of a Novel Series of Thiadiazole-Based Anticancer Agents as Potent Angiogenesis Inhibitors

Altug-Tasa B., Kaya-cavusoglu B., Koparal A. T., TURAN G., Koparal A. S., KAPLANCIKLI Z. A.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.21, sa.15, ss.2041-2049, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 15
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1871520621666201231143535
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.2041-2049
  • Anahtar Kelimeler: Benzothiazole, thiadiazole, thiazole, anticancer activity, angiogenesis, MTT, WST-1, 1,3,4-THIADIAZOLE, DERIVATIVES, BENZOTHIAZOLES, CYTOTOXICITY, ANTIOXIDANT, CARCINOMA, MOIETY
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: Thiadiazole has attracted a great deal of interest as a versatile heterocycle for the discovery and development of potent anticancer agents. Thiadiazole derivatives exert potent antitumor activity against a variety of human cancer cell lines through various mechanisms.