Determination of Sotalol in tablets and serum by CZE

Dogrukol-Ak D., Dal A. G., Tuncel M.

CHROMATOGRAPHIA, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1365/s10337-007-0312-9
  • Dergi Adı: CHROMATOGRAPHIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: capillary zone electrophoresis, sotalol in tablets and serum, LIQUID-CHROMATOGRAPHIC DETERMINATION, RESTRICTED-ACCESS MATERIAL, BIOLOGICAL-FLUIDS, HUMAN PLASMA, ENANTIOSELECTIVE DETERMINATION, IN-VITRO, ENANTIOMERS, ARRHYTHMIAS, ELECTROPHORESIS, DISPOSITION
  • Anadolu Üniversitesi Adresli: Evet

Özet

A validated capillary zone electrophoretic method for analysis of sotalol is described. Analysis was performed in a fused-silica capillary with 20 mM phosphate buffer (pH 4.20) containing 10% (v/v) acetonitrile as background electrolyte. The applied potential was +20 kV, the injection time 0.08 min, signal detection was at 200 nm, and 3,4-dihydoxybenzylamine was used as internal standard. The method was validated over the concentration range 1.98 x 10(-5) to 9.90 x 10(-5) M; repeatability was good and there was no interference. Highly satisfactory results were obtained from analysis of tablets and serum, indicating the method is specific, accurate, and precise, and suitable for routine analysis of sotalol in pharmaceutical tablets and in pharmacokinetic studies.