SYNTHESIS AND ANTIVIRAL ACTIVITY OF SOME (3,4-DIARYL-3H-THIAZOL-2-YLIDENE)PYRIMIDIN-2-YL AMINE DERIVATIVES

Turan-Zitouni G., ÖZDEMİR A., KAPLANCIKLI Z. A.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.186, no.2, pp.233-239, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 186 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1080/10426507.2010.494643
  • Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.233-239
  • Keywords: Antiviral activity, pyrimidine, thiazole, HIV-1, ANALOGS, VIRUS
  • Anadolu University Affiliated: Yes

Abstract

Thirteen new (3,4-diaryl-3H-thiazol-2-ylidene) pyrimidin-2-yl amine derivatives were synthesized by reacting 1-aryl-3-pyrimidin-2-yl-thiourea derivatives and phenacyl bromides in absolute ethanol. The solid that separated was filtered and recrystallized from ethanol. The structures of the synthesized compounds were confirmed by elemental analyses and H-1 NMR, C-13 NMR, and EI-MS spectral data.