Research Information System
Acta Pharmaceutica Turcica, vol.45, no.1, pp.11-15, 2003 (Scopus)
The purpose of this study was to prepare prolonged release tablet formulations of hydralazine hydrochloride which has been used as an antihypertensive agent. To achieve this, carbomers (Carbopol® 834, 934, 940 and 1342) were used as polymer in different concentrations. Magnesium stearate was used as lubricant and direct compression method was applied for preparing tablets. Tests on tablets prepared according to different formulations were carried out in respect of their content uniformity, diameter-height ratio, weight deviation, hardness, friability and in vitro dissolution rate of the drug. Spectrophotometric method was used for hydralazine hydrochloride assay. USP XXII basket method was performed for the in vitro dissolution studies and dissolution data were evaluated kinetically.