Enantiomeric Distribution of Some Linalool Containing Essential Oils and Their Biological Activities

ÖZEK T., Tabanca N., DEMİRCİ F., Wedge D. E., BAŞER K. H. C.

RECORDS OF NATURAL PRODUCTS, vol.4, no.4, pp.180-192, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 4
  • Publication Date: 2010
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.180-192
  • Keywords: Linalool, Chiral separation, Enantiomer, MDGC-MS, Lipodex E, Colletotrichum, Biological activity, Essential oil, GAS-CHROMATOGRAPHY, SOUTHERN BRAZIL, LIPPIA-ALBA, CONSTITUENTS, ANTINOCICEPTION, AROMA, (-)-LINALOOL, CULTIVARS, BOLIVIA, ACETATE
  • Anadolu University Affiliated: Yes


The enantiomeric composition of linalool was determined in 42 essential oils using chiral columns. Essential oils were analyzed by multidimentional gas chromatography-mass spectrometry using a non-chiral and chiral FSC columns combination with modified gamma-cyclodextrine (Lipodex E) as the chiral stationary phase without previous isolation of the compound from the mixture. The essential oils of Achillea, Ballota, Calamintha, Micromeria, Hedychium, Tanacetum, Coriandrum, Xanthoxylum, Ocimum, Thymus, Lavandula, Elettaria, Cinnamomum, Salvia, Origanum, Satureja, Nepeta, Stachys were used as source material for enantiomeric separation of linalool. Enantiomeric distribution of linalool showed (-)-linalool was much more common than the (+)-linalool in the essential oils in this study. (-)- and (+)-linalool enantiomers were evaluated for antimicrobial, antifungal and antimalarial activities. Both enantiomers demonstrated approximately 50% growth inhibition of Botrytis cinerea at 48 hrs.