Effects of lipoprotein-associated phospholipase A2 on arginase/nitric oxide pathway in hemodialysis patients

Tektaş A. K., Uslu S., YALÇIN A. U., ŞAHİN G., Temiz G., Kara M., ...Daha Fazla

Renal Failure, cilt.34, sa.6, ss.738-743, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3109/0886022x.2012.681535
  • Dergi Adı: Renal Failure
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.738-743
  • Anahtar Kelimeler: arginase, hemodialysis, Lp-PLA2, nitric oxide, ENDOTHELIAL ARGINASE, UREMIC PATIENTS, CORONARY, A(2), ARGININE, SESSION, RISK, MARKERS, DISEASE, PLASMA
  • Anadolu Üniversitesi Adresli: Evet

Özet

Lipoprotein-associated phospholipase A2 (Lp-PLA2) and arginase are recently described inflammatory biomarkers associated with cardiovascular disease. In this study, we aimed to investigate the possible effects of serum Lp-PLA2 mass levels on arginase/nitric oxide (NO) pathway as a cardiovascular risk marker in hemodialysis (HD) patients. Forty-three HD patients and 15 healthy subjects were included in this study. Lipid profile, high sensitivity C-reactive protein (hs-CRP), albumin, creatinine, body mass index (BMI), Lp-PLA2 and total nitrite levels, and arginase activity were determined in serum samples from patients and control subjects. Lp-PLA2 levels were found to be positively correlated with arginase, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, and age and negatively correlated with high-density lipoprotein-cholesterol and total nitrite levels, while there was no correlation with BMI and hs-CRP, albumin, and creatinine levels in HD patients. We conclude that elevated Lp-PLA2 mass levels may contribute to impaired arginase/NO pathway in HD patients and that increased the arginase activity and Lp-PLA2 mass levels with decreased total nitrite levels seem to be useful biochemical markers in terms of reflecting endothelial dysfunction and associated cardiovascular risks in HD patients. © 2012 Informa Healthcare USA, Inc.