A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.)


ŞENOL DENİZ F. S., ERDOĞAN ORHAN İ., KÜRKÇÜOĞLU M., Khan M. T. H., Altintas A., Sener B., ...Daha Fazla

FOOD RESEARCH INTERNATIONAL, cilt.53, sa.1, ss.502-509, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.foodres.2013.05.031
  • Dergi Adı: FOOD RESEARCH INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.502-509
  • Anahtar Kelimeler: Rose, Cholinesterase inhibition, Antioxidant activity, Molecular docking, Phenylethyl alcohol, MOLECULAR-FORCE FIELD, OIL-BEARING ROSE, MITOCHONDRIAL DYSFUNCTION, NEURODEGENERATIVE DISEASES, CONFORMATIONAL ENERGIES, ALZHEIMERS-DISEASE, OXIDATIVE STRESS, ACETYLCHOLINESTERASE, GEOMETRIES, MMFF94
  • Anadolu Üniversitesi Adresli: Evet

Özet

In the current study, neuroprotective effect of the essential oil and aromatic waters of rose was investigated by in vitro and in silico methods. The samples were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Since oxidative damage is associated with neurodegeneration, antioxidant activity of the samples was determined by DPPH radical scavenging, metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. Their chemical composition was elucidated by GC-MS. Anti-cholinesterase effects of the main components (citronellol, geraniol, nerol, and phenylethyl alcohol) were also examined. The rose oil showed a noteworthy inhibition against AChE (60.86 +/- 1.99%) and BChE (51.08 +/- 1.70%) at 1000 mu g/mL and low activity in DPPH radical scavenging and FRAP tests. Phenylethyl alcohol exerted higher cholinesterase inhibition than other components and applied further to molecular docking simulations. Docking and binding energies supporting experimental results show that the compound is more selective towards BChE than AChE. (C) 2013 Elsevier Ltd. All rights reserved.