Studies on thiazolyliminothiazoline derivatives as potential antitubercular agents

KAPLANCIKLI Z. A., Turan-Zitouni G., ÖZDEMİR A.

Fabad Journal of Pharmaceutical Sciences, cilt.34, sa.1, ss.25-31, 2009 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2009
  • Dergi Adı: Fabad Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.25-31
  • Anahtar Kelimeler: Acetic acid ethyl esters, Antitubercular activity, Thiazole
  • Anadolu Üniversitesi Adresli: Evet

Özet

In this study, eight new ethyl {2-[3,4-diaryl-3H-thiazol-2-ylidenamino] thiazol-4-yl}acetate were synthesized by reacting ethyl [2-(3-aryl(thiouredio) thiazol-4-yl]acetate and phenacyl bromides in ethanol. The solid was filtered and recrystallized from ethanol. The chemical structures of the synthesized compounds were proven by elemental analysis, IR, 1H-NMR and MS spectral data. The compounds were evaluated for in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The preliminary results showed that all of the tested compounds were inactive against the test organism.