In vitro biological activity of Salvia fruticosa Mill. infusion against amyloid beta-peptide-induced toxicity and inhibition of GSK-3 beta, CK-1 delta, and BACE-1 enzymes relevant to Alzheimer's disease

GÜRBÜZ P., Dokumaci A. H., GÜNDÜZ M. G., Perez C., GÖGER F., PAKSOY M. Y., ...More

SAUDI PHARMACEUTICAL JOURNAL, vol.29, no.3, pp.236-243, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jsps.2021.01.007
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals
  • Page Numbers: pp.236-243
  • Keywords: Lamiaceae, Neurotoxicity, Molecular modeling, Neuroprotection, Rosmarinic acid, PHENOLIC-COMPOUNDS, FIBRIL FORMATION, DOUBLE-BLIND, ACID, ANTIOXIDANT, SAGE, EXTRACT, OFFICINALIS, PROTEIN, MEMORY
  • Anadolu University Affiliated: Yes


Salvia species have been traditionally used to improve cognition and have been proved to be a potential natural treatment for Alzheimer's disease. Salvia fruticosa Mill. (Turkish sage or Greek sage) demonstrated to have anticholinergic effects in vitro.