New Procaspase Activating Compound (PAC-1) Like Molecules as Potent Antitumoral Agents Against Lung Cancer
LETTERS IN DRUG DESIGN & DISCOVERY, vol.16, no.6, pp.645-655, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 16 Issue: 6
- Publication Date: 2019
- Doi Number: 10.2174/1570180815666180926113040
- Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.645-655
- Keywords: Lung cancer, hydrazone, Procaspase Activating Compound (PAC-1), real-time cell analysis, physicochemical properties, antitumor activity, BENZOTHIAZOLE DERIVATIVES BEARING, CELL-DEATH, ANTIPROLIFERATIVE ACTIVITY, BIOLOGICAL EVALUATION, APOPTOSIS, ANTICANCER, GROWTH, PACLITAXEL, DISCOVERY, ANALOGS
- Anadolu University Affiliated: Yes
Abstract
Background: In this study, novel ortho-hydroxy N-acyl hydrazone moiety including compounds (3a-l) were designed, based on procaspase activating compound (PAC-1) which is a small molecule known with antitumor activity. The antitumor activity was evaluated on A549 (human lung cancer cell line) and CCD 19Lu (human lung normal cell line).