New Procaspase Activating Compound (PAC-1) Like Molecules as Potent Antitumoral Agents Against Lung Cancer
LETTERS IN DRUG DESIGN & DISCOVERY, cilt.16, sa.6, ss.645-655, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 6
- Basım Tarihi: 2019
- Doi Numarası: 10.2174/1570180815666180926113040
- Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.645-655
- Anahtar Kelimeler: Lung cancer, hydrazone, Procaspase Activating Compound (PAC-1), real-time cell analysis, physicochemical properties, antitumor activity, BENZOTHIAZOLE DERIVATIVES BEARING, CELL-DEATH, ANTIPROLIFERATIVE ACTIVITY, BIOLOGICAL EVALUATION, APOPTOSIS, ANTICANCER, GROWTH, PACLITAXEL, DISCOVERY, ANALOGS
- Anadolu Üniversitesi Adresli: Evet
Özet
Background: In this study, novel ortho-hydroxy N-acyl hydrazone moiety including compounds (3a-l) were designed, based on procaspase activating compound (PAC-1) which is a small molecule known with antitumor activity. The antitumor activity was evaluated on A549 (human lung cancer cell line) and CCD 19Lu (human lung normal cell line).