Wound healing effect of naringin gel in alloxan induced diabetic mice Alloksan ile diyabet olusturulmus farelerde naringin jelin yara iyilestirici etkiler

Creative Commons License

Okur M. E., Sakul A. A., Ayla S., Karadag A. E., Senyüz C. S., BATUR Ş., ...More

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.44, no.3, pp.397-414, 2020 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.33483/jfpau.742224
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.397-414
  • Keywords: Cell culture, Diabetes mellitus, Het-cam, Naringin, Wound healing
  • Anadolu University Affiliated: Yes

Abstract

© 2020 University of Ankara. All rights reserved.Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound. Material and Method: In vitro direct contact assay and hen's egg chorio-allantoin membrane tests were used to evaluate irritation, and cytotoxicity potential of Naringin. In vitro antimicrobial activity was also tested. Topical treatments were administered once a day on the wound. Wound lesions were photographed and statistically analyzed. After the 10th day, histopathological parameters of tissues were assessed. Result and Discussion: The results showed that naringin gel has no cytotoxicity and irritation potential. Also, it displayed a weak antimicrobial effect. Aside from these, in vivo studies revealed that naringin gel showed statistically higher wound contraction and re-epithelialization, the thickness of granulation tissue, angiogenesis scores. The results indicated that naringin gel effectively enhanced diabetic wound healing, and so this formulation could be considered a promising therapeutic alternative for treating diabetic wounds.