Wound healing effect of naringin gel in alloxan induced diabetic mice Alloksan ile diyabet olusturulmus farelerde naringin jelin yara iyilestirici etkiler

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Okur M. E., Sakul A. A., Ayla S., Karadag A. E., Senyüz C. S., BATUR Ş., ...More

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.44, no.3, pp.397-414, 2020 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.33483/jfpau.742224
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.397-414
  • Keywords: Cell culture, Diabetes mellitus, Het-cam, Naringin, Wound healing
  • Anadolu University Affiliated: Yes


© 2020 University of Ankara. All rights reserved.Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound. Material and Method: In vitro direct contact assay and hen's egg chorio-allantoin membrane tests were used to evaluate irritation, and cytotoxicity potential of Naringin. In vitro antimicrobial activity was also tested. Topical treatments were administered once a day on the wound. Wound lesions were photographed and statistically analyzed. After the 10th day, histopathological parameters of tissues were assessed. Result and Discussion: The results showed that naringin gel has no cytotoxicity and irritation potential. Also, it displayed a weak antimicrobial effect. Aside from these, in vivo studies revealed that naringin gel showed statistically higher wound contraction and re-epithelialization, the thickness of granulation tissue, angiogenesis scores. The results indicated that naringin gel effectively enhanced diabetic wound healing, and so this formulation could be considered a promising therapeutic alternative for treating diabetic wounds.