Antibacterial activities of the methanol extracts, fractions and compounds from Harungana madagascariensis Lam. ex Poir. (Hypericaceae)

Tankeo S. B., Damen F., Sandjo L. P., ÇELİK İ., Tane P., Kuete V.

JOURNAL OF ETHNOPHARMACOLOGY, vol.190, pp.100-105, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 190
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jep.2016.06.005
  • Journal Name: JOURNAL OF ETHNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.100-105
  • Keywords: Antibacterial, Ferruginin A, Kaempferol-3-O-beta-D-glucopyranoside, Madagascin, Crude extract, Multi-drug resistance, CAMEROONIAN MEDICINAL-PLANTS, ANTIMICROBIAL ACTIVITY, STEM BARK, BACTERIA, MORACEAE, CONSTITUENTS, PRODUCTS
  • Anadolu University Affiliated: Yes

Abstract

Ethnopharmacological relevance: Harungana madagascariensis Lam. ex Poir. (Hypericaceae) is used in folk medicine to treat a variety of human ailments, mainly antibacterial, antifungal, antiviral and viral infections. In the present study, the methanol extract from the leaves (HML) and bark (HMB) of this plant as well as fractions (HMBa-c), sub-fractions (HMBal-5) and compounds isolated from HMBa and HMBb namely betulinic acid (1), madagascin (2), ferruginin A (3) and Kaempferol-3-O-beta-D-glucopyranoside (4) were tested for their antimicrobial activities against a panel of 28 g-negative bacteria including multi drug resistant (MDR) phenotypes.