Synthesis and antimicrobial activity of some pyrazoline derivatives bearing amide moiety
MARMARA PHARMACEUTICAL JOURNAL, vol.17, no.3, pp.187-192, 2013 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 17 Issue: 3
- Publication Date: 2013
- Doi Number: 10.12991/2013171314
- Journal Name: MARMARA PHARMACEUTICAL JOURNAL
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.187-192
- Keywords: pyrazoline, amide, furan, thiophene, antimicrobial activity, BIOISOSTERISM, ANTIBACTERIAL, RESISTANCE, SERIES
- Open Archive Collection: AVESIS Open Access Collection
- Anadolu University Affiliated: Yes
Abstract
In the present study, a series of pyrazoline derivatives were synthesized. The chemical structures of the compounds were elucidated by IR, H-1-NMR, C-13-NMR and FAB+-MS spectral data and elemental analyses. The synthesized compounds were screened for their antimicrobial activities. All compounds exhibited the highest antibacterial activity against P. aeruginosa. All compounds except compounds 1-(chloroacetyl)-3-(2-furanyl)-5-(4chlorophenyl)-2-pyrazoline and 1-(chloroacetyl)-3-(2-thienyl)-5-(3,4-methylenedioxyphenyl)2-pyrazoline are more effective than ketoconazole against C. albicans, whereas compounds 1-(chloroacetyl)-3-(2-furanyl)-5-(4-chlorophenyl)-2-pyrazoline, 1-(chloroacetyl)-3-(2-thienyl)-5-( 3,4-methylenedioxyphenyl)-2-pyrazoline and ketoconazole showed the same level of antifungal activity against C. albicans.