Synthesis and antimicrobial activity of some pyrazoline derivatives bearing amide moiety

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ÖZDEMİR A.

MARMARA PHARMACEUTICAL JOURNAL, cilt.17, sa.3, ss.187-192, 2013 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.12991/2013171314
  • Dergi Adı: MARMARA PHARMACEUTICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.187-192
  • Anahtar Kelimeler: pyrazoline, amide, furan, thiophene, antimicrobial activity, BIOISOSTERISM, ANTIBACTERIAL, RESISTANCE, SERIES
  • Anadolu Üniversitesi Adresli: Evet

Özet

In the present study, a series of pyrazoline derivatives were synthesized. The chemical structures of the compounds were elucidated by IR, H-1-NMR, C-13-NMR and FAB+-MS spectral data and elemental analyses. The synthesized compounds were screened for their antimicrobial activities. All compounds exhibited the highest antibacterial activity against P. aeruginosa. All compounds except compounds 1-(chloroacetyl)-3-(2-furanyl)-5-(4chlorophenyl)-2-pyrazoline and 1-(chloroacetyl)-3-(2-thienyl)-5-(3,4-methylenedioxyphenyl)2-pyrazoline are more effective than ketoconazole against C. albicans, whereas compounds 1-(chloroacetyl)-3-(2-furanyl)-5-(4-chlorophenyl)-2-pyrazoline, 1-(chloroacetyl)-3-(2-thienyl)-5-( 3,4-methylenedioxyphenyl)-2-pyrazoline and ketoconazole showed the same level of antifungal activity against C. albicans.