Levocetirizine Dihydrochloride-Loaded Chitosan Nanoparticles: Formulation and In Vitro Evaluation

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Yurtdaş Kırımlıoğlu G., Öztürk A. A.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.17, no.1, pp.27-35, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.4274/tjps.galenos.2018.34392
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.27-35
  • Keywords: Levocetirizine dihydrochloride, chitosan, polymeric nanoparticle, spray drying, DRUG-DELIVERY-SYSTEMS, CETIRIZINE DIHYDROCHLORIDE, MICROSPHERES, VIVO, RELEASE
  • Anadolu University Affiliated: Yes


Objectives: The aim of the present study was to formulate levocetirizine hydrochloride (LCD)-loaded chitosan nanoparticles at submicron level with high entrapment efficiency and prolonged effect for optimizing the plasma drug concentration enhancing bioavailability.
Materials and Methods: LCD was successfully incorporated into chitosan nanoparticles by spray drying for the purpose of oral application. In vitro characteristics were evaluated in detail.

Results: LCD was successfully loaded into the polymeric matrices by spray drying. Characterization of the nanoparticles including encapsulation efficiency, particle size, zeta potential, morphology, polydispersity index, solid-state characterizations, and LCD quantification by high performance liquid chromatography was performed. The release pattern of LCD from the nanoparticles was determined using a dialysis tube in simulated intestinal fluid (pH 6.8). In vitro release profiles indicated prolonged release of LCD from the nanoparticles that followed the Korsmeyer-Peppas kinetic model.

Conclusion: Chitosan-based LCD-loaded polymeric nanoparticles appear to be a promising drug delivery system for the active agent. Key words: Levocetirizine dihydrochloride, chitosan, polymeric nanoparticle, spray drying