Synthesis and anticandidal activity of some imidazopyridine derivatives

KAPLANCIKLI Z. A., Turan-Zitouni G., ÖZDEMİR A., Revial G.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.23, no.6, pp.866-870, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1080/14756360701811114
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.866-870
  • Keywords: Imidazo[1, 2-a]pyridine, hydrazone, anticandidal activity, INFECTIONS, HYDRAZONES, CLOTRIMAZOLE, EPIDEMIOLOGY, HYDRAZIDES, MICONAZOLE, RESISTANCE, THERAPY, AGENTS, ACID
  • Anadolu University Affiliated: Yes

Abstract

New hydrazide derivatives of imidazo[1,2-a]pyridine have been synthesized and evaluated for anticandidal activity. The reaction of imidazo[1,2-a]pyridine-2-carboxylic acid hydrazides with various benzaldehydes gave N-(benzylidene)imidazo[1,2-a]pyridine-2-carboxylic acid hydrazide derivatives. Their anticandidal activities against Candida albicans and Candida glabrata (isolates obtained from Osmangazi University, Faculty of Medicine, Eskisehir, Turkey), Candida albicans (ATCC 90028), Candida utilis (NRLL Y-900), Candida tropicalis (NRLL Y-12968), Candida krusei (NRLL Y-7179), Candida zeylanoides (NRLL Y-1774), and Candida parapsilosis (NRLL Y-12696) were investigated.