Akademik Veri Yönetim Sistemi
JOURNAL OF RESEARCH IN PHARMACY, cilt.28, sa.6, 2024 (Scopus)
Oil Rose (Rosa x damascena Mill.) has a great economic value in food, pharmaceutical and cosmetic
industries with its essential oil obtained by hydrodistillation. Essential oils are usually volatile at room temperature and
they have strong biological effects. These aromatic natural extracts have been used for centuries for their therapeutic
properties. Turkish Rose oil has great economic value for Türkiye and is widely used in current aromatherapy
applications with its sedative and relaxing effects, besides its usage in cosmetic and fragrance industries. Furthermore,
rose oil is one of the preferred aromatherapy oils for increasing the quality of life of cancer patients during
chemotherapy. In this study, the cytotoxic, proapoptotic and antibacterial effects of rose oil and its major component
citronellol were studied on A549 human lung cancer cells and Beas-2B healthy human lung epithelial cells. Antibacterial
tests were performed with CLSI methods. For cytotoxicity test MTT technique was used. Results showed, cytotoxicity
(IC50 value of 16.9 μg/mL), antiproliferative, antibacterial (MIC value of 750 μg/mL) and proapoptotic effects of
citronellol. Additionally, morphological and ultrastructural changes indicating apoptosis were detected. Based on the
findings, structural alterations in mitochondria and cell membranes, along with chromatin condensation and apoptotic
alterations, were observed in A549 cells. Rose oil and citronellol induced apoptosis in both cell lines at different
concentrations.