Some 6-substituted 3-aryl-7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thione derivatives and their antimicrobial activities
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.182, sa.8, ss.1793-1803, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 182 Sayı: 8
- Basım Tarihi: 2007
- Doi Numarası: 10.1080/10426500701323333
- Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Sayfa Sayıları: ss.1793-1803
- Anahtar Kelimeler: 7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thione, antimicrobial activity, thiazole, POTENTIAL ANTI-MICROBIALS, ANTICANCER, HIV
- Anadolu Üniversitesi Adresli: Evet
Özet
In this study, 3-aryl-6-substituted thiazolopyrimidin-2(3H)-thione derivatives 4 and 6 have been synthesized by reacting thiazolopyrimidines 2 with omega-bromoacetophenone 3 and 2-chloro-N-(2-thiazolyl)acetamides 5. The structure elucidation of the obtained compounds was performed by IR, H-1-NMR, MASS spectroscopy, and elemental analyses. The antibacterial and antifungal activities of the compounds were investigated, and it was reported that the compounds showed remarkable antimicrobial activities.