Some 6-substituted 3-aryl-7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thione derivatives and their antimicrobial activities

Demirayak S., Ali F. D., Osman B. S., Tunali Y.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.182, no.8, pp.1793-1803, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 182 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.1080/10426500701323333
  • Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.1793-1803
  • Keywords: 7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thione, antimicrobial activity, thiazole, POTENTIAL ANTI-MICROBIALS, ANTICANCER, HIV
  • Anadolu University Affiliated: Yes

Abstract

In this study, 3-aryl-6-substituted thiazolopyrimidin-2(3H)-thione derivatives 4 and 6 have been synthesized by reacting thiazolopyrimidines 2 with omega-bromoacetophenone 3 and 2-chloro-N-(2-thiazolyl)acetamides 5. The structure elucidation of the obtained compounds was performed by IR, H-1-NMR, MASS spectroscopy, and elemental analyses. The antibacterial and antifungal activities of the compounds were investigated, and it was reported that the compounds showed remarkable antimicrobial activities.