Cytocompatibility property evaluation of gas pressure sintered SiAlON-SiC composites with L929 fibroblast cells and Saos-2 osteoblast-like cells

Kumar, Alok; Mallik, Awadesh; Acikbas, Nurcan; Yaygingol, Merve; Kara, FERHAT; Mandal, HASAN; Basu, Debabrata; Biswas, Krishanu; Basu, Bikramjit

doi:10.1016/j.msec.2011.11.019

Cytocompatibility property evaluation of gas pressure sintered SiAlON-SiC composites with L929 fibroblast cells and Saos-2 osteoblast-like cells

Atıf İçin Kopyala

Kumar A., Mallik A. K., Acikbas N. C., Yaygingol M., Kara F., Mandal H., ...Daha Fazla

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, cilt.32, sa.3, ss.464-469, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 32 Sayı: 3
Basım Tarihi: 2012
Doi Numarası: 10.1016/j.msec.2011.11.019
Dergi Adı: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.464-469
Anahtar Kelimeler: SiAlON, SiC, Composite, In vitro, Cytocompatibility, STRUCTURAL ORTHOPEDIC IMPLANTS, IMPROVED FRACTURE-TOUGHNESS, SILICON-NITRIDE, CYTOTOXICITY EVALUATION, MICROSTRUCTURAL DESIGN, PHASE-TRANSFORMATIONS, MECHANICAL-PROPERTIES, METAL RELEASE, CARBIDE, ALUMINA
Anadolu Üniversitesi Adresli: Evet

Özet

Although the oxide ceramics have widely been investigated for their biocompatibility, non-oxide ceramics, such as SiAlON and SiC are yet to be explored in detail. Lack of understanding of the biocompatibility restricts the use of these ceramics in clinical trials. It is hence, essential to carry out proper and thorough study to assess cell adhesion, cytocompatibility and cell viability on the non-oxide ceramics for the potential applications. In this perspective, the present research work reports the cytocompatibility of gas pressure sintered SiAlON monolith and SiAlON-SiC composites with varying amount of SIC, using connective tissue cells (L929) and bone cells (Saos-2). The quantification of cell viability using MTT assay reveals the non-cytotoxic response. The cell viability has been found to be cell type dependent. An attempt has been made to discuss the cytocompatibility of the developed composites in the light of SiC content and type of sinter additives. (C) 2011 Elsevier B.V. All rights reserved.