Synthesis of some hydrazone derivatives bearing purine moiety as anticancer agents Antikanser ajanlar olarak pürin parçasi{dotless} taşi{dotless}yan bazi{dotless} hidrazon türevlerinin sentezi

Zitouni G. T., ALTINTOP M. D., ÖZDEMİR A., KAPLANCIKLI Z. A., DİKMEN M.

Turkish Journal of Pharmaceutical Sciences, cilt.11, sa.1, ss.55-65, 2014 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2014
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.55-65
  • Anahtar Kelimeler: Anti-proliferative activity, Cancer, Hydrazone, Purine
  • Anadolu Üniversitesi Adresli: Evet

Özet

In the present study, some hydrazone derivatives were synthesized via the reaction of 6-hydrazino-9-(β-D-ribofuranosyl)-9H-purine with various benzaldehydes. The structures of the compounds were elucidated by spectroscopic techniques such as 1H-NMR, 13C-NMR and ES-MS and elemental analyses. Anti-proliferative activity tests were performed on human lung (A549) and breast (MCF-7) cancer cell lines using MTT assay. Some derivatives were found to be effective against A549 and MCF-7 cell lines among these compounds. They exhibited time and dose dependent anti-proliferative activity against A549 and MCF-7 cancer cell lines.