A Novel and Sensitive LC-MS/MS Method for the Quantitation of Ceftiofur in Pharmaceutical Preparations and Milk Samples

LEVENT S., ÖZCAN S., Geven A., CAN N. Ö.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, cilt.24, sa.3, ss.386-399, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1386207323999201110192558
  • Dergi Adı: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.386-399
  • Anahtar Kelimeler: Ceftiofur, solvent-based calibration, LC-MS/ MS, matrix-matched calibration, milk analysis, monolithic silica column, BETA-LACTAM ANTIBIOTICS, MULTIRESIDUE ANALYSIS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Introduction: In the present study, a sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was described for the determination of ceftiofur (CEF) in cow milk and pharmaceutical preparations. CEF is an antibiotic compound, which is commonly used in the treatment of animal diseases such as respiratory system, soft tissue, and foot infections, as well as postpartum acute puerperal metritis. One of the critical features of CEF is its prescription while breastfeeding cows; in accordance, its quantitative estimation is essential to assess its residual amounts.