Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives

Maillard L. T., Bertout S., Quinonero O., AKALIN ÇİFTÇİ G., Turan-Zitouni G., Fulcrand P., ...Daha Fazla

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.23, sa.6, ss.1803-1807, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.bmcl.2013.01.039
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.1803-1807
  • Anahtar Kelimeler: Thiazole, Hydrazone, Candida spp., Antifungal activity, IN-VITRO ACTIVITY, RESISTANCE, CYTOTOXICITY
  • Anadolu Üniversitesi Adresli: Evet

Özet

Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species. (C) 2013 Elsevier Ltd. All rights reserved.