Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives

Maillard L. T., Bertout S., Quinonero O., AKALIN ÇİFTÇİ G., Turan-Zitouni G., Fulcrand P., ...More

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.23, no.6, pp.1803-1807, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1016/j.bmcl.2013.01.039
  • Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.1803-1807
  • Keywords: Thiazole, Hydrazone, Candida spp., Antifungal activity, IN-VITRO ACTIVITY, RESISTANCE, CYTOTOXICITY
  • Anadolu University Affiliated: Yes

Abstract

Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species. (C) 2013 Elsevier Ltd. All rights reserved.