Synthesis and Anticancer Activities of Some Thiazole Derivatives

Kayagil I., DEMİRAYAK Ş.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.184, no.9, pp.2197-2207, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 184 Issue: 9
  • Publication Date: 2009
  • Doi Number: 10.1080/10426500802446181
  • Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.2197-2207
  • Keywords: Anticancer activity, poly-thiazole, thiazolone, 2,4-DISUBSTITUTED THIAZOLES, ANALOGS, AGENTS
  • Anadolu University Affiliated: Yes

Abstract

In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.