Poly-Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Containing Ketoprofen Lysine: Preparation and Characterization


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Elmaskaya A., Öztürk A. A., Yenilmez E.

12. Internation Symposium on Pharmaceutical Sciences (ISOPS 12), Ankara, Turkey, 26 - 29 June 2018, pp.296

  • Publication Type: Conference Paper / Full Text
  • City: Ankara
  • Country: Turkey
  • Page Numbers: pp.296
  • Anadolu University Affiliated: Yes

Abstract

Ketoprofen lysine (KL), the water soluble lysine salt of Ketoprofen, is one of the most widely used non- steroidal anti-inflammatory drugs (NSAIDs) in the symptomatic treatment of various chronic inflammatory diseases for its analgesic efficacy. However, due to its short half-life of 1–2 h, a multiple dose regimen is required therefore, KL is an ideal candidate for the development of controlled drug delivery systems which are able to release the drug at a desired rate and in desired amount. PLGA exhibits many of the ideal properties of a nanoscale delivery system, providing long term release of the encapsulated agent and degrading into the biocompatible products of lactic and glycolic acid (2). According to the aim of this study, KL-containing PLGA nanoparticles were prepared by spray drying method.