Research Information System
12. Internation Symposium on Pharmaceutical Sciences (ISOPS 12), Ankara, Turkey, 26 - 29 June 2018, pp.315, (Full Text)
Ketoprofen lysinate (KL), the water soluble lysine salt of ketoprofen, is one of the most commonly used non-steroidal anti-inflammatory drug (NSAIDs) in the symptomatic treatment of various chronic inflammatory diseases. However, due to its short half-life of 1–2 h, a multiple dose regimen is required. Therefore, KL is an ideal candidate for the development of controlled drug delivery systems which are able to release the drug at a desired rate and in desired amount. Eudragit S 100 is an anionic copolymer based on methacrylic acid and methyl methacrylate. It is generally used for the formulation of transdermal patches, nanoparticles, microparticles, solid dispersions and spherical crystals. Eudragit S 100 has been used for various applications such as sustain release, bioavailability enhancement, improvement in micrometric properties. According to the aim of this study, KL-containing Eudragit S100 nanoparticles were prepared by double emultion solvent evaporation method.