Synthesis and characterization of complexes of a novel proton transfer salt and their inhibition studies on carbonic anhydrase isoenzymes
Journal of Enzyme Inhibition and Medicinal Chemistry, vol.30, no.2, pp.195-203, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 30 Issue: 2
- Publication Date: 2015
- Doi Number: 10.3109/14756366.2014.908290
- Journal Name: Journal of Enzyme Inhibition and Medicinal Chemistry
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.195-203
- Keywords: 2-Amino-6-chlorobenzothiazole, 2,6-pyridinedicarboxylic acid, carbonic anhydrase, proton transfer, statistical analyses, DIPICOLINATE, BENZOXAZOLE, DERIVATIVES, ESTERASE
- Anadolu University Affiliated: No
Abstract
© 2014 Informa UK Ltd.A novel proton transfer compound (HClABT)+(HDPC.H2DPC)- (1) and its Fe(III), Co(II), Ni(II) and two different Cu(II) complexes (2-6) have been prepared and characterized by spectroscopic techniques. Additionally, single crystal X-ray diffraction techniques were applied to all complexes. All compounds, including acetazolamide (AAZ) as the control compound, were also evaluated for their in vitro inhibition effects on human hCA I and hCA II for their hydratase and esterase activities. Although there is no inhibition for hydratase activities, all compounds have inhibited the esterase activities of hCA I and II. The comparison of the inhibition studies of 1-6 to parent compounds, ClABT and H2DPC, indicates that 1-6 have superior inhibitory effects. The inhibition effects of 2-6 are also compared to the inhibitory properties of the simple metal complexes of ClABT and H2DPC, revealing an improved transfection profile. Data have been analysed by using a one-way analysis of variance for multiple comparisons.